Ferroptosis Mediates Cuprizone-Induced Loss of Oligodendrocytes and Demyelination
نویسندگان
چکیده
منابع مشابه
Gas6 Increases Myelination by Oligodendrocytes and Its Deficiency Delays Recovery following Cuprizone-Induced Demyelination
Multiple sclerosis (MS) is a complex demyelinating disease of the central nervous system. Current research has shown that at least in some cases, the primary insult in MS could be directed at the oligodendrocyte, and that the earliest immune responses are primarily via innate immune cells. We have identified a family of receptor protein tyrosine kinases, known as the TAM receptors (Tyro3, Axl a...
متن کاملGAS6 Enhances Repair Following Cuprizone-Induced Demyelination
Growth arrest-specific protein 6 (gas6) activities are mediated through the Tyro3, Axl, and Mer family of receptor tyrosine kinases. Gas6 is expressed and secreted by a wide variety of cell types, including cells of the central nervous system (CNS). In this study, we tested the hypothesis that administration of recombinant human Gas6 (rhGas6) protein into the CNS improves recovery following cup...
متن کاملProtective effects of erythropoietin against cuprizone-induced oxidative stress and demyelination in the mouse corpus callosum
Objective(s): Increasing evidence in both experimental and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of multiple sclerosis. The aim of the present work is to investigate the protective effects of erythropoietin against cuprizone-induced oxidative stress. Materials and Methods: Adult male C57BL/6J mice were fed a chow containing 0.2 % cuprizone for 6 ...
متن کاملGas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination.
The TAM family of receptor protein tyrosine kinases comprises three known members, namely Tyro3, Axl, and Mer. These receptors are widely expressed in the nervous system, including by oligodendrocytes, the cell type responsible for myelinating the CNS. We examined the potential role of the TAM family and of their principle cognate ligand, Gas6 (growth arrest gene 6), in modulating the phenotype...
متن کاملAn Alternative Cuprizone-Induced Demyelination and Remyelination Mouse Model
The cuprizone model is a well-established and investigated paradigm to study demyelination and remyelination in rodents. Cuprizone is usually administrated by mixing in the powdered or pelleted rodent chow. However, since cuprizone is sensitive to the environment and the consumption of it varies between different animals, the major issue is the discrepancy in demyelination of the animals. This ...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 2020
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.1749-20.2020